Neutrophils are part of the granulocyte family and play an important role in innate immunity. Neutrophils or polymorphonuclear neutrophils (PMNs) make up the largest proportion of circulating leukocytes. Patients with low PMN counts (neutropenia) or functional defects in PMN are more likely to be overwhelmed by infection. Granulocyte-reactive antibodies have been shown to play a key role in the pathophysiology of several immune-mediated neutropenias, transfusion-related acute lung injury (TRALI), auto-immune neutropenia after bone marrow transplantation and febrile transfusion reactions. Post-transfusion, in TRALI, the donor-derived antibodies can cause inappropriate activation of neutrophils leading to damage of the pulmonary microvasculature with severe clinical consequences. Thus, these disorders demand rapid and precise diagnosis using reliable neutrophil serology.
We encourage and support new and emerging granulocyte laboratories through education and organisation of practical workshop-like sessions. We provide access to like-minded colleagues active in (diagnostic) laboratory, research and/or clinical settings in all aspects of granulocyte immunobiology. We discuss standards for serology diagnostics and are involved in education and training programmes for new laboratories. Our WP supports scientific co-operation between our members and organises meetings. We establish and monitor nomenclature for human neutrophil alloantigens (HNA). Moreover, we develop standards for laboratory diagnostics of TRALI and compatibility testing of granulocyte concentrates, detection of anti-granulocyte antibodies, -antigens and we characterise granulocyte antibody-mediated disorders. We support and promote the HNA nomenclature subcommittee.
Our Chairperson is Behnaz Bayat.
We meet at the ISBT congresses and organise International educational Workshops every other year. Also, we regularly organise the exchange of typing sera and typed DNA.
Membership is open to all ISBT members actively working in a (diagnostic) laboratory, research, clinical setting and/or pharmaceutical company of the field of Granulocyte Immunobiology.
Interested in joining the Granulocyte Immunobiology WP? Please email our Chairperson.
Some of the content is only accessible for ISBT-members. To join us, click here.
Follow this link to visit ISBT Education and watch the interview with Lin Fung and Ulrich Sachs. The talk was recorded at the 27th Regional Congress of the ISBT in Copenhagen.
- Update on the nomenclature of human neutrophil antigens and alleles Transfusion. 2016 Jun;56(6):1477-9.
- External quality assessment of human neutrophil antigen (HNA)-specific antibody detection and HNA genotyping from 2000 to 2012 Vox Sang. 2013 Oct;105(3):259-69.
- Bleeding or no bleeding? Anti‐endothelial alphaVbeta3 antibodies as a major cause of intracranial haemorrhage in fetal–neonatal alloimmune thrombocytopenia ISBT Science Series 2017 Dec; 13, 59–69, doi.org/10.1111/voxs.12401
For a list of HNA alleles and antigens click here.