Aim of the webinar:
- Understand transfusion difficulties in sickle cell disease and implement appropriate analyses.
- Prevent, diagnose and treat post-transfusion hemolysis in patients with sickle cell disease
Level of education required:
3-5
What knowledge is required?
- Basic immuno hematology, basic red blood cell physiology and pathophysiology
- Knowledge of basic transfusion protocols
We'd recommend you to read the below publications before the webinar
- Thein SL, Pirenne F, Fasano RM, Habibi A, Bartolucci P, Chonat S, Hendrickson JE, Stowell SR. Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal. Haematologica. 2020 Mar;105(3):539-544. doi: 10.3324/haematol.2019.224709. Epub 2020 Feb 6. PMID: 32029505; PMCID: PMC7049330.
- Chou ST, Alsawas M, Fasano RM, Field JJ, Hendrickson JE, Howard J, Kameka M, Kwiatkowski JL, Pirenne F, Shi PA, Stowell SR, Thein SL, Westhoff CM, Wong TE, Akl EA. American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support. Blood Adv. 2020 Jan 28;4(2):327-355. doi: 10.1182/bloodadvances.2019001143. PMID: 31985807; PMCID: PMC6988392.
- Pirenne F, Yazdanbakhsh K. How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions. Blood. 2018 Jun 21;131(25):2773-2781. doi: 10.1182/blood-2018-02-785964. Epub 2018 May 3. PMID: 29724898; PMCID: PMC6014354.
- Chou ST, Hendrickson JE. How I Treat Challenging Transfusion Cases in Sickle Cell Disease. Blood. 2024 May 10:blood.2023023648. doi: 10.1182/blood.2023023648. Epub ahead of print. PMID: 38728382.
Target audience
Scientists, blood bankers, transfusion practitioners, practitioners in immuno hematology laboratory
Please be aware that if you attend the webinar, your data will be shared with Grifols Diagnostic. If you do not want your data to be shared, please send us an email at [email protected].
The Speakers
France Pirenne
Professor of Hematology/Transfusion at the University Paris Est Créteil (UPEC) and the CHU Henri Mondor in Créteil, Medical director of the Etablissement français du sang (EFS).
Her expertise is focused on the transfusion of sickle-cell patients, a vulnerable population due to their geographical origin.
Her clinical research team was the first to highlight specific post-transfusion accidents in sickle-cell patients, whether or not associated with rare blood groups. These patients were maiden to receive the new preventive and curative treatments in France and overseas (anti-CD20, Eculizumab).
She is the author of more than 150 scientific publications and reviews. In 2020, Prof. Pirenne was invited by the American Association of Hematology to contribute to the recommendations review for the transfusion of sickle-cell patients.
France Pirenne works with teams in sub-Saharan Africa to improve the immunological safety of transfusions in sickle cell disease.
Greg Denomme
Dr. Denomme is a life-long career scientist in transfusion medicine. He has post-graduate training in immunohematology, obtained a doctorate in microbiology and immunology, and completed postdoctoral fellowships in platelet immunology and pathology and molecular medicine. Dr. Denomme recently transitioned to Director of Medical Affairs at Grifols Diagnostic Solutions.
