Quality management in transfusion medicine has the primary goal of providing blood components of the required quality for safe and effective transfusion treatment. In order to achieve this goal, it is necessary to implement a quality system that incorporates the principles of good practice and quality risk management. An effective quality system should cover all processes in blood supply chain, from blood collection to the use of blood components. Continuous quality monitoring is essential to compare current and expected quality level and to identify opportunities for improvement.