Clinical Transfusion


promote good clinical transfusion practice globally through education, audits and scientific studies

Clinical transfusion comprises all clinical aspects of blood transfusion and promotes safe practice and appropriate use of blood (components). This includes both the risks and benefits of transfusion as well as close monitoring of patients. Patients should only be transfused when there is evidence for potential benefit. Occasionally, transfusion alternatives might be considered. In order to optimize patient care in need for blood transfusion, it is crucial to follow an evidence-based, multidisciplinary approach. Patient Blood Management (PBM) comprises patient evaluation and clinical management surrounding this decision-making process. This includes application of appropriate indications, minimization of blood loss and optimization of patient red cells. PBM can reduce allogeneic blood transfusions and health-care costs, while ensuring that blood components are available for patients.



We develop educational tools in clinical transfusion medicine both for clinicians and transfusion specialists, medical and non-medical. We support ISBT's library of evidence-based guidelines, audits and perform benchmarks. We also exchange knowledge with other transfusion specialists for optimizing clinical transfusion practice.

We have the following subgroups:

  • Patient Blood Management (PBM): our website (led by Birgit Gathof) provides PBM resources and tools for implementation, educational activities such as eLearning (led by Cynthia So-Osman and Peter van den Burg) (in progress), Wikipedia project (led by Lise Estcourt), live Journal Club (led by Mark Yazer), I TRY IT co-mentorship,  and performing global benchmark surveys (several subgroups).
  • 'Transfusion Practitioners' (TP, chaired by Linley Bielby and  Rachel Moss) provide a forum for transfusion practitioners to connect and share knowledge. The Transfusion Practitioners also have their own online discussion forum on the ISBT Forum. If you are interested in joining the forum, please email for more information.
  • Paediatric (Paeds, chaired by Gemma Crighton). This subgroup (formerly the Paediatrics WP) provides tools for PBM implementation and eLearning regarding neonates and children. Click here to navigate to the Paediatrics Subgroup webpage.
  • Shared WHO projects (led by Cynthia So-Osman) such as revision of Clinical use of Blood Manual.

Our Chairperson is Cynthia So-Osman, and our Vice Chairperson is Mark Yazer.



We meet at ISBT congresses and organize annual interim business meetings (located in Amsterdam) and teleconferences within the subgroups (2-3 times per year).

Joining the WP

ISBT members who are interested in clinical transfusion can join this WP only if they have demonstrated an interest in clinical transfusion medicine.

To join the WP of Clinical Transfusion, please email our Chairperson here.

Working Party Forum

The Clinical Transfusion Working Party has its own sub-forum on the ISBT Community Forum. If you have any questions related to clinical transfusion or the WP you are welcome to post your questions here. On the forum you will also find the Transfusion Practitioners forum, a forum for members of our Transfusion Practitioner subgroup. 



Some of the content is only accessible for ISBT-members.
To join us, click here.

Online course

The University Of Melbourne offers 2 transfusion based courses:
• Specialist Certificate in Blood Management Foundations
• Graduate Certificate in Transfusion Practice.

Both are online courses offered by the University of Melbourne School Of Nursing and delivered under the auspice of the Blood Matters Program, a collaboration between the Australian Red Cross Blood Service and The Department of Health.

Each course is offered part time over one semester. The Specialist Certificate is offered in Semester one and is a pre-requisite for the Graduate Certificate which is delivered in Semester 2.

Semester 1
• Foundations in Blood Management (25 credit points)
This subject provides an introduction to the concepts of patient blood management (PBM), & National Safety and Quality HealthCare Standards relating to blood. The subject supports the development of specific skills, and provides information to assist health services to meet these standards.

Upon successful completion the student will obtain a Specialist Certificate in Blood Management Foundations from the University of Melbourne.

Semester 2
• Advanced Concepts in Blood Management (12.5 credit points)
This subject builds on the knowledge and expertise gained in the Foundations in Blood Management subject to provide advanced knowledge of relevant clinical practice guidelines and PBM strategies.

•Quality Practice Portfolio (12.5 points)
This is a practical subject that embeds prior learnings by facilitating the application of knowledge and skills to the clinical setting.

Upon successful completion the student will obtain a Graduate Certificate in Transfusion Practice from the University of Melbourne.

For more information click here. Or click here to access the flyer.


  1. Patient Blood Management initiatives on a global level: the results of an International Society of Blood Transfusion Survey C. So‐Osman, D. E. van der Wal, S. Allard on behalf of the ISBT Working Party Clinical Transfusion ISBT Science Series 2017 May, 12, 327–335,
  2. Development of RBC transfusion indications and the collection of patient-specific pre-transfusion information: summary M. Yazer et al Vox Sanguinis (2017) 112, 487–494
  3. Vox Sanguinis International Forum on the use of prehospital blood products and pharmaceuticals in the treatment of patients with traumatic haemorrhage Yazer, Spinella, Allard, Roxby, So-Osman, Lozano, Gunn, Shih, Stensballe, Johansson, Bagge Hansen, Maegele, Doughty, Crombie, Jenkins, McGinity, Schaefer, Martinaud, Shinar, Strugo, Chen & Russcher Vox Sanguinis (2018) 113, 701–706
  4. Patient Blood Management Recommendations From the 2018 Frankfurt Consensus Conference Mueller, Van Remoortel, Meybohm, Aranko, Aubron, Carson, Cichutek, De Buck, Devine, Fergusson, Folléa, French, Frey, Gammon, Levy, Murphy, Ozier, Pavenski, So-Osman, Tiberghien, Volmink, Waters, Wood, Seifried, for the ICC PBM Frankfurt 2018 Group JAMA. 2019;321(10):983-997. doi:10.1001/jama.2019.0554

Patient Blood Management - a great Resource



Patient Blood Management (PBM) is an evidence-based, multidisciplinary approach aimed at optimising the care of patients who might need transfusion. It puts the patient at the heart of decisions made around blood transfusion, promoting appropriate use of blood and blood components and the timely use of alternatives where available. PBM represents an international initiative in best practice for transfusion medicine. The Clinical Transfusion Working Party have put together this resource to help support the wider implementation of PBM. It represents experience from a number of countries and contains 14 chapters on various aspects of PBM.


Please click on the hyperlinks below to access the chapters.

1. Potential benefits to patients and the healthcare system  

2. Establishing and implementing a PBM strategy 

3. Pre-operative optimisation of haemoglobin

4. Tranexamic acid

5. Red cell transfusion triggers in Adults

6. Single unit Transfusion

7. Platelet Transfusion

8. Obstetric anaemia 

9. Neonatal red blood cell transfusion

10. The Role of the Transfusion Practitioner 

11. The Role of Transfusion Committees

12. Use of IT to support PBM 

13. Audit

14. Transfusion in Hemoglobinopathies


Cynthia So-Osman

Cynthia So-Osman


Sanquin Blood Supply
the Netherlands